Omalizumab Improves Efficacy of Oral Immunotherapy for Multiple Food Allergies

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Monday December 11, 2017

Omalizumab Improves Efficacy of Oral Immunotherapy for Multiple Food Allergies

Bowl of peanuts, egg, and glass of milk

Combining a 16-week initial course of omalizumab with oral immunotherapy (OIT) greatly improves the efficacy of OIT for children with allergies to multiple foods, results from a NIAID-funded clinical trial show. After 36 weeks, more than 80 percent of children who received omalizumab and OIT could safely consume two-gram portions of at least two foods to which they were allergic, compared with only a third of children who received placebo and OIT. 

The findings suggest the potential benefits of using omalizumab to safely and rapidly facilitate desensitization to multiple food allergens. Additional, larger studies will be needed to confirm and expand on these promising results.

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