NHLBI Media Availability: NIH Ends Transcranial Doppler (TCD) with Transfusions Changing to Hydroxyurea (TWiTCH) Clinical Trial Due to Early Results

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November 19, 2014

NIH Ends Transcranial Doppler (TCD) with Transfusions Changing to Hydroxyurea (TWiTCH) Clinical Trial Due to Early Results
The National Heart, Lung, and Blood Institute has ended the Transcranial Doppler (TCD) with Transfusions Changing to Hydroxyurea (TWiTCH) clinical trial early in agreement with the recommendations of the Data and Safety Monitoring Board (DSMB). The results of this study show that hydroxyurea is not inferior to (that is, no worse than) regular blood transfusions in lowering TCD blood velocities in children with sickle cell disease who are at high risk for stroke.

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